What are the drug interactions of Cabozantinib?

Some medications are absolutely contraindicated for combined use. For other medications, even if drug interactions may occur, they can still be used under the guidance of a physician. In such cases, the doctor may adjust the dosage or take other necessary preventive measures.

What are the drug interactions of Cabozantinib?

During treatment with this medication, you must inform your healthcare providers of all the following drugs you are taking (the interactions listed are screened based on potential clinical significance and do not cover all possibilities):

Not recommended for combined use: The doctor may discontinue Cabozantinib or adjust other medications you are taking.

Bacillus Calmette-Guérin (BCG) vaccine (live attenuated vaccine).

Quadrivalent dengue live attenuated vaccine.

Measles live attenuated vaccine.

Mumps live attenuated vaccine.

Rubella live attenuated vaccine.

Smallpox/monkeypox vaccine.

Typhoid vaccine.

Varicella live attenuated vaccine.

Yellow fever vaccine.

Impact of other conditions on Cabozantinib

Other medical conditions may affect the use of this medication. Be sure to inform your doctor of all your other health conditions, especially the following:

Hemorrhagic disorders, thrombotic diseases, acute myocardial infarction, heart disease, uncontrolled hypertension, hypocalcemia, hypothyroidism, proteinuria, gastric fistula/perforation, recent stroke: Use with caution; these conditions may be exacerbated.

Dental problems, dental procedures/surgery, poor oral hygiene, dental infections: May increase the risk of severe jaw disorders.

Recent hematemesis, hemoptysis, history of severe bleeding, melena: Contraindicated.

Mild to moderate liver disease: Use with caution; delayed drug clearance may enhance the drug’s efficacy.

Severe liver disease: Contraindicated.

Storage of Cabozantinib

Store in a sealed container at room temperature, away from heat sources, moisture, direct sunlight, and do not freeze.

Keep out of reach of children.

Do not retain expired or unused medications. Consult your healthcare provider for proper disposal methods.