What are the capmatinib drug interactions?

Capmatinib, trade name Tabrecta. It is an oral MET inhibitor mainly used for the treatment of non-small cell lung cancer with MET exon 14 skipping mutations. The drug can effectively inhibit the proliferation and survival of MET-dependent cancer cells.

What are the capmatinib drug interactions?

With the drug on the market in China and widely used in clinical practice, both doctors and patients should pay attention to drug interactions, which are summarized as follows according to clinical studies:

1. CYP1A2 substrate

Concomitant use of CYP1A2 substrates may lead to serious adverse effects and should be avoided, with common drugs including caffeine, aflatoxin B1, and paracetamol.

2. P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) substrates

The use of these substrates may cause serious adverse effects, and combinations should be avoided, including pazopanib, everolimus, digoxin, dabigatran etexilate, rivaroxaban, and apixaban.

What are the precautions for capmatinib?

According to the drug leaflet, patients need to pay attention to the following important points when using this medicine:

1. Embryo-fetal toxicity

Patients should be counseled about the potential risk of capmatinib causing harm to the fetus, and effective contraception during medication treatment is recommended.

2. Pancreatic toxicity

In 14% of patients in the study, amylase and lipase levels were elevated after capmatinib, and regular monitoring of amylase and lipase levels before and during treatment was recommended, and consideration of suspending, tapering, or permanent discontinuation of the drug if necessary.

What are the adverse effects of capmatinib?

Like other medications, capmatinib can also have some side effects during use. Patients should be fully aware of these possible side effects before receiving treatment:

1. Peripheral edema

The severity of edema can affect the patient's daily activities and may cause discomfort and difficulty moving. For severe edema, measures such as dose adjustments or diuretics may be needed to reduce symptoms.

2. Vomiting

Vomiting is often accompanied by nausea, which worsens discomfort. Frequent vomiting can lead to dehydration and electrolyte imbalances, requiring medical intervention in severe cases. Patients should choose light, easy-to-digest foods to reduce symptoms.

[Warm tips] The treatment of lung diseases is a long-term process, and patients should maintain a positive and optimistic attitude, actively communicate with the doctor, and follow the doctor's instructions to take the medicine on time and in accordance with the dosage.