What to look out for when using Pemigatinib

Pemigatinib is a small-molecule kinase inhibitor targeting FGFR1, 2, and 3 by inhibiting phosphorylation and signaling of these receptors, thereby inhibiting tumor cell proliferation and survival.

What to look out for when using Pemigatinib

During the treatment of Pemigatinib, patients may experience the side effect of hyperphosphatemia, which can induce a variety of adverse reactions such as soft tissue mineralization, skin calcification, calcinosis, and non-uremic calcification. The root cause of this side effect is that Pemigatinib causes an abnormal increase in phosphate levels in the body as a direct consequence of its pharmacodynamics.

Drug interactions with Pemigatinib

Pemigatinib may interact with certain food drugs during use, affecting the therapeutic effect, and patients and their families need to be aware of it.

Pemigatinib may interact with inducers and inhibitors of the CYP3A enzyme, affecting its metabolism and efficacy. Patients should avoid concomitant use of strong and moderate CYP3A inducers during the medication period and may need to reduce the dose of Pemigatinib if concomitant use of strong and moderate CYP3A inhibitors cannot be avoided.

How to avoid drug interactions

In order to avoid interactions during treatment, the following points should be noted.

1. Fully understand the patient's medication history

Before prescribing drugs, doctors should ask for and understand the patient's medication history in detail, including prescription drugs, over-the-counter drugs, Chinese herbal medicines, and health products.

By asking patients whether they have used similar drugs in the past and whether there are any adverse effects, the likelihood of drug interactions can be predicted so that treatment can be developed and adjusted.

2. Focus on high-risk populations

The elderly, children, pregnant women, and people with reduced liver and kidney function have a weak ability to metabolize and excrete drugs and are prone to drug interactions and adverse reactions.

Doctors should be extra cautious when prescribing medications for these populations and try to avoid medications with a higher risk of interactions.

3. Focus on drugs with low therapeutic index

Drugs with a low therapeutic index usually have a narrow safety range and are prone to adverse effects. When using this type of drug, doctors should pay special attention to interactions with other drugs to avoid the occurrence of adverse reactions.

【Warm tips】When patients buy generic drugs, they should choose formal channels to ensure the quality and safety of the drugs. Avoid purchasing counterfeit products from informal sources.