Standard Dosage and Adjustment Principles for Tepotinib

Standard Dosage and Adjustment Principles for Tepotinib

The recommended dose is 2 tablets (i.e., 450 mg) orally once daily, taken with or shortly after a meal to ensure adequate absorption. This dose may be continued long-term as long as clinical benefit is observed and adverse reactions are tolerable. If intolerable toxicity occurs, the physician may reduce the dose to 1 tablet (225 mg) daily or temporarily interrupt treatment for a few days until symptoms resolve, then resume. Do not adjust the dose on your own.

Alternative Administration for Patients with Difficulty Swallowing Tablets

For patients who have difficulty swallowing tablets, place 2 tablets in a cup, add 30 mL of room-temperature water (non-carbonated), and stir for several minutes until the tablets disintegrate into small particles (they will not completely dissolve). Drink the suspension within 1 hour. To ensure the full dose is taken, rinse the cup with another 30 mL of water and drink it. If the patient has a nasogastric tube of at least 8 French gauge, prepare the suspension in the same manner and push it through the tube within 1 hour, then flush the cup and syringe twice with 30 mL of water each time to ensure no drug residue remains and the entire dose has been delivered.

Management of Missed Dose and Overdose for Tepotinib

If you forget to take a dose, take it as soon as you remember; however, if it is less than 8 hours until your next scheduled dose, skip the missed dose and take the next one at the regular time. Never double the dose to make up for a missed one. Regarding overdose, clinical experience is limited, but it is presumed that overdose symptoms may resemble common adverse reactions (such as nausea, diarrhea, edema, etc.). If you suspect an overdose, contact your doctor immediately for timely assessment and management.