Asciminib(Scemblix)

Asciminib is a prescription drug approved by the U.S. Food and Drug Administration (FDA) on October 29, 2021. It targets the BCR-ABL1 fusion protein, including the T315I mutant, and shall be used strictly in accordance with medical advice.)

Lucius Related Certificates

Drug Testing Report

Drug Approval Certificate

Target of Action

BCR-ABL1 fusion protein (including T315I mutation type).

Dosage and Administration

Route and frequency of administration for asciminib: Oral.

Dosage adjustment of asciminib should be based on the patient's actual condition; specific situations require consultation with a physician and adherence to medical advice.

Recommended reading: Dosage and administration of asciminib

Side Effects

Common side effects: Muscle, bone, or joint pain, rash, fatigue, etc.

Serious side effects: Low blood cell counts, pancreatic problems, etc.

Reference article: Side effects of asciminib

Use in Special Populations

Pregnancy: You should use effective contraception during treatment with SCEMBLIX and for 1 week after the last dose.

Breastfeeding: It is not known whether SCEMBLIX passes into breast milk. Do not breastfeed during treatment with SCEMBLIX and for 1 week after the last dose.

Daily Precautions

1. Inform patients of the possibility of cytopenia. Advise patients to immediately notify healthcare providers if they develop fever, suspected signs of infection, or signs/symptoms related to bleeding or easy bruising.

2. Inform patients that pancreatitis may occur, which may be accompanied by symptoms such as nausea, vomiting, severe abdominal pain, or abdominal discomfort. Seek medical attention promptly if these symptoms occur.

3. Inform patients of the possibility of hypertension. If blood pressure increases or symptoms such as confusion, headache, dizziness, chest pain, or shortness of breath occur, patients should contact healthcare providers promptly.

from FDA,2021.10