Is Pemigatinib good for cholangiocarcinoma?

Pemigatinib is used in adults to treat bile duct cancer that has spread to other parts of the body (metastatic) or cannot be removed with surgery. 

Is Pemigatinib good for cholangiocarcinoma?

The clinical trial FIGHT-202 is a pivotal clinical trial of Pemigatinib evaluating its efficacy in the treatment of patients with locally advanced or metastatic cholangiocarcinoma with FGFR2 fusion or rearrangement. Results from the trial showed an overall response rate (ORR) of 36% and a disease control rate (DCR) of 82% with Pemigatinib monotherapy. This suggests that Pemigatinib is effective in controlling tumor growth and spread in most patients.

The median overall survival (mOS) of Pemigatinib was 21.1 months, significantly prolonging the survival of patients compared to the 6-7 months of historical mean survival in patients who received the second and third lines of treatment. This clinical trial data shows that Pemigatinib can effectively treat cholangiocarcinoma patients and brings new hope for cholangiocarcinoma patients.

Pemigatinib side effects

Pemigatinib has significant efficacy in the treatment of diseases with FGFR2 fusion or rearrangement, such as cholangiocarcinoma, but it may also be accompanied by a series of adverse reactions.

1. Eye problems

eye pain or redness, dry or puffy eyes, watery eyes, your eyes may be more sensitive to light.

2. Vision changes

blurred vision, seeing black spots or "floaters," or seeing flashes of light.

3. High phosphate levels in your blood

muscle cramps, numbness, and tingly feeling around your mouth.

Preparation for the administration of Pemigatinib

Before patients are treated with Pemigatinib, they should confirm the conditions of use with their doctor, noting the following.

1. Diagnosis and examination

Before starting Pemigatinib, it is necessary to confirm whether the patient does have FGFR2 fusion or rearrangement, which is an indication for this drug.

2. Physical examination

Patients should undergo a thorough physical examination to assess basic conditions such as liver and kidney function to ensure that they can tolerate drug therapy.

3. Medication guidance

Patients should follow their doctor's recommendations and medication guidelines to understand how to use the medication, dosage, and precautions.

【Warm tips】When patients buy generic drugs, they should choose formal channels to ensure the quality and safety of the drugs. Avoid purchasing counterfeit products from informal sources.