Absolute Contraindications and Allergic Reactions to Crizotinib

Absolute Contraindications and Allergic Reactions to Crizotinib

Crizotinib is contraindicated in the following situations: hypersensitivity to crizotinib or any other ingredients in the capsule (such as colloidal anhydrous silica, microcrystalline cellulose, gelatin, titanium dioxide, etc.). Allergic reactions may manifest as rash, dyspnea, or more severe systemic reactions. Patients should ensure they have no known history of allergies.

Important Medical History to Disclose to Your Doctor in Advance

Before starting treatment, you must inform your doctor of the following conditions: moderate or severe liver disease; any history of lung problems (as crizotinib may cause a lung inflammation-like reaction, leading to dyspnea, cough, or fever); a diagnosis of prolonged QT interval on ECG (a type of heart rhythm disorder); slow pulse; history of gastrointestinal perforation, diverticulitis, or abdominal tumor metastases; presence of visual disturbances (flashes, blurred vision, or double vision); severe renal impairment. If any of these conditions apply, your doctor may need to perform additional tests or adjust the treatment plan.

Emergency Symptoms to Watch for During and After Crizotinib Treatment

While taking crizotinib or after completing treatment, if you experience any of the following severe symptoms, contact your doctor immediately: severe abdominal pain or lower abdominal pain, fever, chills, shortness of breath, palpitations, partial or complete vision loss in one or both eyes, changes in bowel habits. Additionally, if you develop new or worsening dyspnea, productive or dry cough, unusual fatigue, yellowing of the skin or eyes, dark urine, nausea and vomiting, loss of appetite, right-sided abdominal pain, skin itching, or unusual bruising, seek urgent medical attention. Your doctor may monitor liver and kidney function through blood tests and adjust the dose or discontinue treatment based on the results.